Treatment of Severe Drug Reactions 1. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
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چکیده
SJS and TEN are variants of the same process, presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. The cutaneous lesions often become confluent and show a positive Nikolsky sign and epidermal detachment. In SJS, epidermal detachment involves less than 10% of the total body skin area; transitional SJS-TEN is defined by an epidermal detachment between 10 and 30%; TEN is defined by a detachment greater than 30%. Full-thickness epidermal necrosis is observed on pathological examination. This clinical definition separates SJS-TEN from erythema multiforme major.
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